Ryan Fee's 6 Max NL Strategy Guide

Preface: This book will cover small stakes online 6 max ring games. All hands will be assumed to be 6 handed, though other situations will be discussed. The focus of this book will be the progression of a hand through preflop, flop, turn, and river.
Your hand ranges in general should adjust and be contrary to the way the game is playing.
This means that if the game is loose (meaning there are a lot of bad players, generally players with VPIP's higher than 28, for example a player that plays 32/5/1 is a weak bad player) you should be playing a tighter more solid game, bluffing less often (including semi-bluffs) and value betting thinly with 1 pair type hands. You should also play less starting hands.
On the flip side if the game is tighter you should loosen up your starting range (incorporating hands such as 65s UTG) to exploit the your opponent's tendency to fold. In these instances you should semi-bluff and bluff more, as you will find more fold equity.
Loose players will search for an excuse to call, whereas a tight player will look for an excuse to fold.

Ryan Fees 6max NL Guide
Study Group at 2+2